Description
Here’s a breakdown of what’s currently known about the benefits of 5-Amino-1MQ in mammalian (especially rodent) studies, based on preclinical research and early reports:
Mechanism of Action
- Inhibits NNMT: The compound selectively blocks nicotinamide N-methyltransferase (NNMT), an enzyme widely expressed in liver and adipose tissue, critical in metabolic regulation Peptide SciencesReddit.
- Boosts NAD+ and Activates SIRT1: This inhibition leads to elevated intracellular NAD⁺ levels and stabilization or activation of SIRT1 (“the longevity gene”), which are instrumental in cellular energy metabolism, stress response, and longevity pathways nuutro.co.ukThe Peptide ReportRedditpeptideresearcher.com.
Observed Benefits in Mammalian Models (Primarily Mice)
- Weight & Fat Reduction: In diet-induced obese (DIO) mice, 5-Amino-1MQ notably reduced body weight, white adipose tissue mass, adipocyte size, and plasma cholesterol—without affecting food intake or showing adverse effects nuutro.co.ukPeptide SciencesReddit+1.
- Improved Lipid Metabolism: In adipocyte and DIO animal assays, the compound reduced lipogenesis by 50–70% and decreased adipocyte volume by over 40%, plus lowered plasma lipids by ~30% Peptide SciencesReddit.
- Enhanced Muscle Regeneration: Especially in aged mice, treatment led to nearly double the muscle fiber cross-sectional area (CSA), improved muscle stem cell proliferation, and shifts toward larger myofibers—suggesting improved regenerative and neuromuscular capacity nuutro.co.ukReddit.
- Metabolic Rate & Mitochondrial Function: Reports indicate enhanced metabolic rate via better mitochondrial efficiency and cellular energy production The Peptide Report+1.
Additional Potential Benefits (Mechanistic Insights & Anecdotal Reports)
- Anti-Inflammatory & Anti-Aging: Inhibition of NNMT may lower inflammation and cellular senescence by maintaining NAD⁺, enhancing SIRT1 activity, and supporting cellular repair capacity nuutro.co.ukThe Peptide ReportRedditpeptideresearcher.com.
- Cancer-related Effects: Preliminary suggestions exist that 5-Amino-1MQ might inhibit cancer cell proliferation or sensitize tumors to chemotherapy by disrupting metabolic pathways and activating AMPK-related mechanisms—though this is far from confirmed in vivo Genesis Health Institutenuutro.co.uk.
- Cognitive and Energy Support: Anecdotal observations (mostly forum-based) mention improved focus, sustained energy, and reduced muscle soreness—likely tied to metabolic efficiency and anti-inflammatory actions.
