Description
1 CAPSULE = 250MCG
Contains 60 Capsules
SLU-PP-332 is a synthetic agonist of estrogen-related receptors (ERRα/β/γ) that has demonstrated promising results in animal studies, particularly in mouse models of obesity and metabolic syndrome. These studies suggest that SLU-PP-332 can mimic the metabolic benefits of exercise without requiring increased physical activity or changes in food intake.PMC+4PubMed+4ResearchGate+4
Key Findings from Animal Studies1. Enhanced Fatty Acid Oxidation and Energy Expenditure
In both diet-induced obese (DIO) and ob/ob mice, SLU-PP-332 administration led to a significant increase in fatty acid oxidation and resting energy expenditure. This metabolic shift was evidenced by a lower respiratory exchange ratio (RER), indicating a preference for fat as an energy source over carbohydrates. Notably, these effects occurred without changes in food consumption or physical activity levels .PMC+1PubMed+1
2. Reduction in Fat Mass and Body Weight
Treated mice exhibited substantial reductions in fat mass and overall body weight. For instance, DIO mice experienced approximately a 12% decrease in body weight over a 28-day treatment period, despite no significant alterations in diet or activity .Technology Networks+2PMC+2PubMed+2
3. Improved Glucose Metabolism in Obese Models
While SLU-PP-332 did not significantly affect glucose metabolism in lean, chow-fed mice, it improved glucose tolerance and reduced fasting insulin levels in obese models. This suggests potential benefits for insulin sensitivity in the context of obesity .PubMed+1PMC+1PMC
4. Enhanced Muscle Function and Endurance
The compound increased oxidative muscle fibers (type IIa) and mitochondrial activity, leading to improved exercise endurance. Mice treated with SLU-PP-332 were able to run approximately 50% further than control groups, indicating enhanced muscle function .University of Florida News+3PubMed+3Fortune+3Technology Networks
5. Reduction in Liver Fat and Improved Lipid Profiles
SLU-PP-332 treatment resulted in decreased hepatic triglyceride content and reduced signs of liver steatosis. Additionally, treated mice showed lower levels of total cholesterol and triglycerides, indicating improved lipid metabolism
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